• 黃則度

    有機化學

    副教授,博士生導師

    huangzedu@fudan.edu.cn

    沐鸣平台手性分子催化與合成工程中心A207室

    13817525134

    研究興趣

    • 新穎酶催化和生物催化反應的發現與應用

    • 手性藥物與手性技術的研究

    • 合成生物學

    學習工作經歷

    • 2003.9-2007.6         浙江大學沐鸣开户本科,獲得學士學位

    • 2007.9-2012.8         加拿大阿爾伯塔大學沐鸣开户研究生👨‍❤️‍👨,獲得博士學位

    • 2012.11-2016.10        美國伊利諾伊大學香檳分校,博士後

    • 2016.11-2022.11        沐鸣开户,青年研究員

    • 2022.12起                 沐鸣开户,副教授

    授課情況

    • 本科生必修課程《有機化學》

    • 本科生必修課程《有機化學實驗I》

    代表性論文或專著

    • Wu, X.; Yang, L.; Liu, Z.; Zhang, K.; Huang, Z.;* Chen, F.* Ene-Reductase-Catalyzed Enantioselective Desymmetrization of Cyclohexadienones: Straightforward Access to All-Carbon Quaternary Stereocenters. ACS Catal. 2024, 14, 6194-6202.

    • Zhu, K.; Jiang, M.; Ye, B.; Zhang, G.; Li, W.; Tang, P.; Huang, Z.;* Chen, F.* A Unified Strategy to Prostaglandins: Chemoenzymatic Total Synthesis of Cloprostenol, Bimatoprost, PGF2, Fluprostenol, and Travoprost Guided by Biocatalytic Retrosynthesis. Chem. Sci. 2021, 12, 10362-10370.

    • Hu, P.; Wu, X.; Zhang, Y.; Liu, M.; Tao, Y.; Huang, Z.;* Chen, F.* Engineered Ketoreductase-Catalyzed Stereoselective Reduction of Ethyl 2’-Ketopantothenate and Its Analogues: Chemoenzymatic Synthesis of D-Pantothenic Acid. Green Chem.2024, 26, 2124-2134.

    • Zhang, Y.; Liu, M.; Yang, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Batch and Continuous Flow Asymmetric Synthesis of Anabolic-Androgenic Steroids via a Single-Cell Biocatalytic Δ1-Dehydrogenation and C17-Carbonyl Reduction Cascade. Green Chem.2023, 25, 3223-3235.

    • Liu, J.; Wu, X.; Li, Z.; Huang, Z.;* Chen, F.* Engineered Monoamine Oxidase-Catalyzed Deracemization of Sterically Hindered Acylaminomethyl-tetrahydroisoquinoline: Asymmetric Synthesis of (R)‑(−)-Praziquantel and Its Analogues. ACS Sustainable Chem. Eng.2023, 11, 7552-7559.

    • Yue, X.; Li, Y.; Sang, D.; Tao, Y.; Huang, Z.;* Chen, F.* Asymmetric Synthesis of Syn-Aryl-(2S,3R)-2-Chloro-3-Hydroxy Esters via an Engineered Ketoreductase-Catalyzed Dynamic Reductive Kinetic Resolution. Chin. Chem. Lett. 2023, 34, 108178.

    • Li, Y.; Yue, X.; Li, Z.; Huang, Z.;* Chen, F.* Asymmetric Synthesis of Sterically Hindered 1-Substituted Tetrahydro-β-carbolines Enabled by Imine Reductase: Enzyme Discovery, Protein Engineering, and Reaction Development. Org. Lett. 2023, 25, 1285-1289.

    • Yue, X.; Li, Y.; Liu, M.; Sang, D.; Huang, Z.;* Chen, F.* Biocatalytic Dynamic Reductive Kinetic Resolution of Aryl α-Chloro β-Keto Esters: Divergent, Stereocontrolled Synthesis of Diltiazem, Clentiazem, and Siratiazem. Chem. Commun.2022, 58, 9010-9013.

    • Li, Z.; Wang, Z.; Wang, Y.; Wu, X.; Lu, H.; Huang, Z.;* Chen, F.* Substituent Position-Controlled Stereoselectivity in Enzymatic Reduction of Diaryl- and Aryl(heteroaryl)methanones. Adv. Synth. Catal.2019, 361, 1859-1865.  

    • Li, Z.; Yang, H.; Liu, J.; Huang, Z.;* Chen, F.* Application of Ketoreductase in Asymmetric Synthesis of Pharmaceuticals and Bioactive Molecules: An Update (2018-2020). Chem. Rec. 2021, 21, 1611-1630.  

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