師資隊伍
周偉
有機化學
副教授
zhouw@fudan.edu.cn
上海市東安路130號13號樓323室
021-54237431
研究興趣
生物活性評價及作用機製研究🆑：以多種病毒、細菌🍺、腫瘤、肝病、炎症、高血糖、骨質疏松等體內外模型為基礎的生物活性測試平臺👨🏻⚖️，開展小分子化合物活性評價，並生物技術開展活性化合物的作用機製和靶點研究。
超分子化合物生物應用性功能開發（與黎占亭、張丹維老師合作）🧖🏿：利用大環化合物預組織結構以及非共價作用力的協同性和多價性，實現對生物活性客體的高選擇性和高穩定性結合，進而研究與開發新的生物功能性應用。
天然產物以及生物催化合成👷🏼♂️🕯：活性微生物次級代謝產物和天然植物小分子化合物的發現🧅🦹🏼，以及運用基因突變及發酵技術，以微生物為載體🤕，通過調節生物合成途徑🌊，對這些天然產物化學結構進行選擇性修飾，實現綠色合成。
學習工作經歷
1999.9-2003.6 沐鸣平台藥學院,本科
2003.9-2008.6 沐鸣平台藥學院藥物化學專業,博士（碩博連讀）
2008.7-2010.3 浙江海正藥業新藥研發部,項目經理
2010.4-2011.10 美國Ohio University,訪問學者
2011.12-至今 沐鸣开户,講師，副教授
授課情況
合成實驗（上、下）（專業必修課，上海市重點課程）
有機化學實驗（全英語課程，沐鸣平台精品課程）
藥物化學（專業選修課）
有機化學C（專業必修課⚠，上海市重點課程）
代表性論文或專著
Yang Zong, Zhuo Lei, Shang-Bo Yu*, Ling-Yu Zhan g, Yan Wu, Ke Feng, Qiao-Yan Qi, Yamin Liu, Yajie Zhu, Peng Guo, Wei Zhou*, Dan-Wei Zhang, Zhan-Ting Li*. Caltrop-like Small-Molecule Antidotes That Neutralize Unfractionated Heparin and Low-Molecular-Weight Heparin In Vivo. Journal Medicinal Chemistry, 2024, 67, 5, 3860–3873.
YanWu, JingyuYang, Sheng-Yi Zhuang, Shang-BoYu, Yang Zong, Yue-Yang Liu, Gang Wu, Qiao-Yan Qi, Hui Wang, Jia Tian, Wei Zhou*, Da Ma*, Dan-Wei Zhang*, Zhan-Ting Li*. Macrocycles and Acyclic Cucurbit[n]urils as Pseudo[2]catenane Partners for Long-Acting Neuromuscular Blocks and Rapid Reversal In Vivo. Journal Medicinal Chemistry, 2024, 67, 2176-2187.
Wang Xinhua1; Zhou Wei1; Xie Wenlin; Chen Qi; Wu Jie*. Generation of (E)-β- trifluoromethyl vinylsulfonohydrazides under photocatalysis and their anti-bacteria activity. Chinese Chemical Letters, 2023, 34, 107984.
Hong-Kun Liu, Furong Lin, Shang-Bo Yu*, Yan Wu, Shuai Lu, Yue-Yang Liu, Qiao-Yan Qi, Jin Cao, Wei Zhou*, Xiaopeng Li, Hui Wang, Dan-Wei Zhang, Zhan-Ting Li*, Da Ma*. Highly Water-Soluble Cucurbit[8]uril Derivative as a Broad-Spectrum Neuromuscular Block Reversal Agent. Journal Medicinal Chemistry, 2022, 65, 16893−16901.
Yan Wu, Yue-Yang Liu, Hong-Kun Liu, Shang-Bo Yu, Furong Lin, Wei Zhou*, Hui Wang, Dan-Wei Zhang*, Zhan-Ting Li*, Da Ma*. Flexible organic frameworks sequester neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo. Chemical Science, 2022, 13, 9243–9248.
Xuefeng Wang, Jun Zhang, Qi Chen, Wei Zhou*, Jie Wu*. Generation of sulfonylureas under photoredox catalysis and their biological evaluations. Chinese Chemical Letters, 2022, 33, 4860–4864.
Furong Lin, Shang-Bo Yu,* Yue-Yang Liu, Chuan-Zhi Liu, Shuai Lu, Jin Cao, Qiao-Yan Qi, Wei Zhou,* Xiaopeng Li, Yi Liu, Jia Tian, Zhan-Ting Li*. Porous Polymers as Universal Reversal Agents for Heparin Anticoagulants through an Inclusion Sequestration Mechanism. Advanced Materials, 2022, 34, 2200549.
Yamin Liu, Ze-Kun Wang, Zhong-Zheng Gao, Yang Zong, Jian-Da Sun, Wei Zhou*, Hui Wang, Da Ma, Zhan-Ting Li*, Dan-Wei Zhang*. Porous organic polymer overcomes the post-treatment phototoxicity of photodynamic agents and maintains their antitumor efficiency. Acta Biomaterialia, 2022, 150, 254–264.
Yue-Yang Liu, Ze-Kun Wang, Shang-Bo Yu, Yamin Liu, Hui Wang, Wei Zhou*, Zhan-Ting Li*, Dan-Wei Zhang*. Conjugating aldoxorubicin to supramolecular organic frameworks: polymeric prodrugs with enhanced therapeutic efficacy and safety. Jounal of Material Chemistry B, 2022, 10, 4163–4171.
Jun Zhang, Xuefeng Wang, Qi Chen, Jianhe Liu*, Wei Zhou*, Jie Wu*. (E)-β -Trifluoromethyl vinylsulfones as antitumor agents: Synthesis and biological evaluations. European Journal of Medicinal Chemistry, 2022, 232, 114197.
Yang Zong, Yan-Yan Xu, Yan Wu, Yamin Liu, Qian Li, Furong Lin*, Shang-Bo Yu*, Hui Wang, Wei Zhou*, Xing-Wen Sun, Dan-Wei Zhang and Zhan-Ting Li*. Porous dynamic covalent polymers as promising reversal agents for heparipn anticoagulants. Jounal of Material Chemistry B, 2022, 10, 3268-3276.
Shuwen Han, Chunlin Zhuang, Wei Zhou*，Fener Chen*. Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β. Marine Drugs, 2021, 19, 149.
Yun-Yan Kuang, Xuan Gao, Yi-Jun Niu, Xun-Long Shi，Wei Zhou*. Polymorphic characterization, pharmacokinetics, and anti-Inflammatory activity of ginsenoside compound K polymorphs. Molecules, 2021, 26, 1983.
Jiale Lin, Zekun Wang, Ziyue Xu, Lei Wei; Yunchang Zhang*, Hui Wang, Danwei Zhang, Wei Zhou*, Yuebiao Zhang, Yi Liu*; Zhanting Li*. Water-soluble flexible organic frameworks that include and deliver proteins. Journal of the American Chemical Society, 2020, 142, 3577–3582.
Haosha Tang, Yunyan Kuang, Julan Zeng, Xiaofang Li, Wei Zhou*, Yuan Lu*. Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents. RSC Advances, 2019, 9, 31474.
